TF → Target relations
Please be aware that these associations were extracted using large language models (LLMs).
| Modifiers | Transcription factor | Target | Relation type | Text | PMID |
|---|---|---|---|---|---|
| — | PGR | H19 | Negative Regulation | Interestingly, the same experiments performed in BT-20 cell line provided very similar results as those obtained in MCF-7 cells, with a clear down-regulation mediated by PR-A on the H19 promoter. | 10442637 |
| — | SREBF1 | APOA2 | Binding | Overall, the findings suggest that the wild-type SREBP-1 can bind and transactivate efficiently the apoA-II promoter in cell culture. | 10364076 |
| — | SREBF1 | APOA2 | Positive Regulation | Overall, the findings suggest that the wild-type SREBP-1 can bind and transactivate efficiently the apoA-II promoter in cell culture. | 10364076 |
| — | E2F1 | CDKN2A | Neutral Regulation | The E2F1 target gene critical for the senescence response appeared to be the p14(ARF) tumor suppressor. | 10594030 |
| Increased | PDX1 | INS | Positive Regulation | These results suggest that high glucose increased DNA-binding activity of PDX-1 by activating atypical PKC including PKC zeta, resulting in transcriptional activation of the human insulin gene promoter. | 10426567 |
| — | SP1 | Serpinh1 | Binding | These results suggest that two separate elements are necessary for the cell type-specific expression of the hsp47 gene; one is a putative Sp1-binding site at -210 bp necessary for basal expression, and the other is a 500-bp region within the first intron, required for cell type-specific expression. | 10585450 |
| — | SP1 | Serpinh1 | Positive Regulation | These results suggest that two separate elements are necessary for the cell type-specific expression of the hsp47 gene; one is a putative Sp1-binding site at -210 bp necessary for basal expression, and the other is a 500-bp region within the first intron, required for cell type-specific expression. | 10585450 |
| — | FOSL1 | Eln | Binding | Overall the results suggest that bFGF represses elastin gene transcription by increasing the amount of the Fra 1 that subsequently binds to the -564- to -558-bp as a heterodimer with c-Jun to form an inhibitory complex. | 10559225 |
| — | JUN | Eln | Binding | Overall the results suggest that bFGF represses elastin gene transcription by increasing the amount of the Fra 1 that subsequently binds to the -564- to -558-bp as a heterodimer with c-Jun to form an inhibitory complex. | 10559225 |
| — | FOSL1 | Eln | Negative Regulation | Overall the results suggest that bFGF represses elastin gene transcription by increasing the amount of the Fra 1 that subsequently binds to the -564- to -558-bp as a heterodimer with c-Jun to form an inhibitory complex. | 10559225 |
| — | JUN | Eln | Negative Regulation | Overall the results suggest that bFGF represses elastin gene transcription by increasing the amount of the Fra 1 that subsequently binds to the -564- to -558-bp as a heterodimer with c-Jun to form an inhibitory complex. | 10559225 |
| — | FOXE1 | TPO | Positive Regulation | This was confirmed by transfection experiments and by protein-DNA interaction studies, which demonstrated that CTF/NF1 proteins bind 10 base pairs upstream of the TTF-2-binding site to enhance its action in hormone-induced expression of the TPO gene. | 10329730 |
| — | FOXE1 | TPO | Binding | This was confirmed by transfection experiments and by protein-DNA interaction studies, which demonstrated that CTF/NF1 proteins bind 10 base pairs upstream of the TTF-2-binding site to enhance its action in hormone-induced expression of the TPO gene. | 10329730 |
| — | NR0B1 | Star | Negative Regulation | These results imply that DAX-1 has an important role in regulating ovarian steroidogenesis by repressing StAR transcription. | 10403575 |
| — | TP53 | BAX | Positive Regulation | Together, these data suggest a potential mechanism for the differential regulation of p53-dependent transactivation of the bax and p21 genes. | 10559267 |
| — | TP53 | CDKN1A | Positive Regulation | Together, these data suggest a potential mechanism for the differential regulation of p53-dependent transactivation of the bax and p21 genes. | 10559267 |
| — | MITF | TYR | Neutral Regulation | MITF (microphthalmia-associated transcription factor) is a basic-helix-loop-helix-leucine zipper (bHLHZip) factor which regulates expression of tyrosinase and other melanocytic genes via a CATGTG promoter sequence, and is involved in melanocyte differentiation. | 10587587 |
| — | MITF | TYR | Binding | MITF (microphthalmia-associated transcription factor) is a basic-helix-loop-helix-leucine zipper (bHLHZip) factor which regulates expression of tyrosinase and other melanocytic genes via a CATGTG promoter sequence, and is involved in melanocyte differentiation. | 10587587 |
| Increased | NR2F2 | AGT | Negative Regulation | Co-transfection of Arp-1 reduces estrogen induced promoter activity of reporter constructs containing human angiotensinogen gene promoter. | 10221773 |
| Mutant | TP53 | BAG1 | Positive Regulation | Furthermore, the data suggested that overexpression of BAG-1 in some tumors may be due to upregulation of the human BAG-1 promoter by mutant p53. | 10467399 |
| — | PAX6 | L1CAM | Positive Regulation | A binding site for homeodomain and Pax proteins is necessary for L1 cell adhesion molecule gene expression by Pax-6 and bone morphogenetic proteins. | 10051657 |
| — | ELF5 | BPIFA2 | Positive Regulation | Thus, ESE-2, but not ESE-1, transactivates the parotid gland-specific PSP promoter and the prostate-specific PSA promoter. | 10506207 |
| — | ELF5 | KLK3 | Positive Regulation | Thus, ESE-2, but not ESE-1, transactivates the parotid gland-specific PSP promoter and the prostate-specific PSA promoter. | 10506207 |
| — | ZNF148 | COL1A2 | Binding | Here we show that another zinc-finger transcription factor, BFCOL1, which binds to the proximal proalpha2(I) collagen promoter, could also bind to this GC-box of the p21 promoter. | 10066455 |
| — | ZNF148 | CDKN1A | Binding | Here we show that another zinc-finger transcription factor, BFCOL1, which binds to the proximal proalpha2(I) collagen promoter, could also bind to this GC-box of the p21 promoter. | 10066455 |
| Increased | JUN | TNF | Positive Regulation | Forced expression of c-Jun in ATF2-expressing melanoma cells restored TNFalpha expression, suggesting that both forms of ATF2 sequestered transcription factors that positively regulate TNFalpha expression in response to UV irradiation. | 10318823 |
| — | ATF2 | TNF | Negative Regulation | Forced expression of c-Jun in ATF2-expressing melanoma cells restored TNFalpha expression, suggesting that both forms of ATF2 sequestered transcription factors that positively regulate TNFalpha expression in response to UV irradiation. | 10318823 |
| — | RELA | ABCB1 | Negative Regulation | Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region. | 10026303 |
| — | FOS | ABCB1 | Negative Regulation | Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region. | 10026303 |
| — | RELA | ABCB1 | Binding | Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region. | 10026303 |
| — | FOS | ABCB1 | Binding | Negative regulation of MDR1 promoter activity in MCF-7, but not in multidrug resistant MCF-7/Adr, cells by cross-coupled NF-kappa B/p65 and c-Fos transcription factors and their interaction with the CAAT region. | 10026303 |
| — | Tp53 | Pcna | Neutral Regulation | We found that exogenous p53 was unable to mimic the UV irradiation to induce rat PCNA promoter and that the UV induction of the rat PCNA promoter was seen in p53 deficient cells. | 10321841 |
| — | ETS2 | BCL2L1 | Positive Regulation | The bcl-x promoter contains potential Ets binding sites, and we show that the transcription factor, Ets2, first identified by its sequence identity to v-ets of the E26 retrovirus, can transactivate the bcl-x promoter. | 10082528 |
| — | NR5A1 | SCARB1 | Positive Regulation | The results confirm that indeed both SF-1 and SREBP-1a synergize to induce HDL receptor SR-BI gene expression. | 10579331 |
| — | SREBF1 | SCARB1 | Positive Regulation | The results confirm that indeed both SF-1 and SREBP-1a synergize to induce HDL receptor SR-BI gene expression. | 10579331 |
| — | FOXO3 | FASLG | Positive Regulation | Within the nucleus, FKHRL1 triggers apoptosis most likely by inducing the expression of genes that are critical for cell death, such as the Fas ligand gene. | 10102273 |
| — | CEBPA | PRL | Positive Regulation | Expression of C/EBP alpha increased basal PRL gene expression almost 6-fold, whereas expression of Chop10 that can act as an inhibitor of C/EBP alpha reduced the basal activity of the PRL promoter 60-75%. | 10499509 |
| — | DDIT3 | PRL | Negative Regulation | Expression of C/EBP alpha increased basal PRL gene expression almost 6-fold, whereas expression of Chop10 that can act as an inhibitor of C/EBP alpha reduced the basal activity of the PRL promoter 60-75%. | 10499509 |
| — | STAT3 | CDKN1A | Binding | IL-6 dependent upregulation of p21WAF1/CIP1 was associated with binding of both STAT3 and STAT1 to the p21WAF1/CIP1 promoter. | 10023678 |
| — | STAT1 | CDKN1A | Binding | IL-6 dependent upregulation of p21WAF1/CIP1 was associated with binding of both STAT3 and STAT1 to the p21WAF1/CIP1 promoter. | 10023678 |
| — | SPI1 | NCF2 | Positive Regulation | In these studies, we identify an NCF2 cis element, necessary for IFN-gamma-induced p67phox expression, and determine that this element is activated by cooperation between the transcription factors PU.1, IFN regulatory factor 1 (IRF1), and the IFN consensus-binding protein (ICSBP). | 10570299 |
| — | IRF1 | NCF2 | Positive Regulation | In these studies, we identify an NCF2 cis element, necessary for IFN-gamma-induced p67phox expression, and determine that this element is activated by cooperation between the transcription factors PU.1, IFN regulatory factor 1 (IRF1), and the IFN consensus-binding protein (ICSBP). | 10570299 |
| — | IRF8 | NCF2 | Positive Regulation | In these studies, we identify an NCF2 cis element, necessary for IFN-gamma-induced p67phox expression, and determine that this element is activated by cooperation between the transcription factors PU.1, IFN regulatory factor 1 (IRF1), and the IFN consensus-binding protein (ICSBP). | 10570299 |
| — | YY1 | IL3 | Neutral Regulation | Regulation of a cell type-specific silencer in the human interleukin-3 gene promoter by the transcription factor YY1 and an AP2 sequence-recognizing factor. | 10480868 |
| Increased | EGR1 | Me1 | Negative Regulation | These results suggest that insulin induces a quick, transient, and Ras/MAP kinase-dependent activation of Egr-1 which leads to a transient repression of ME gene transcription. | 10364249 |
| Increased | MYC | CDKN1A | Negative Regulation | We show here that exogenous c-Myc inhibits p21 expression in SkBr3 and LNCaP cells induced to enter into S-phase. | 10319992 |
| Increased | ELK4 | EGR1 | Positive Regulation | Coexpression of Sap-1a and Elk-1 resulted in a marked increase in GH induction of egr-1 promoter activity, although transfection with expression vectors for either Ets factor alone did not significantly enhance the GH response. | 10194767 |
| Increased | ELK1 | EGR1 | Positive Regulation | Coexpression of Sap-1a and Elk-1 resulted in a marked increase in GH induction of egr-1 promoter activity, although transfection with expression vectors for either Ets factor alone did not significantly enhance the GH response. | 10194767 |
| Increased | ELK4 | EGR1 | Neutral Regulation | Coexpression of Sap-1a and Elk-1 resulted in a marked increase in GH induction of egr-1 promoter activity, although transfection with expression vectors for either Ets factor alone did not significantly enhance the GH response. | 10194767 |
| Increased | ELK1 | EGR1 | Neutral Regulation | Coexpression of Sap-1a and Elk-1 resulted in a marked increase in GH induction of egr-1 promoter activity, although transfection with expression vectors for either Ets factor alone did not significantly enhance the GH response. | 10194767 |
| — | CEBPA | PRL | Neutral Regulation | These data suggest that C/EBP alpha is an important transcription factor that regulates PRL gene expression. | 10499509 |
| — | EGR3 | FASLG | Positive Regulation | The transcription factors NF-AT and Egr-3 (a member of the immediate-early transcription factors involved in cellular growth and differentiation) have been implicated in activation of the CD95L promoter upon T cell activation. | 10508276 |
| — | IRF1 | IRF2 | Positive Regulation | IRF-1 also induced expression of its homologous repressor IRF-2 as indicated by EMSA analysis using an IRF-E probe from the IRF-2 promoter; and by cotransfection of IRF-1 together with an IRF-2 promoter CAT construct. | 10321737 |
| — | IRF1 | IRF2 | Binding | IRF-1 also induced expression of its homologous repressor IRF-2 as indicated by EMSA analysis using an IRF-E probe from the IRF-2 promoter; and by cotransfection of IRF-1 together with an IRF-2 promoter CAT construct. | 10321737 |
| — | Rbpj | MYOD1 | Negative Regulation | Delta-induced Notch signaling mediated by RBP-J inhibits MyoD expression and myogenesis. | 10066785 |
| — | EGR1 | F3 | Binding | As shown by immunofluorescence and electrophoretic mobility shift assays, upon VEGF treatment EGR-1 rapidly accumulates in the nucleus and binds to its respective recognition site in the tissue factor promoter. | 10339488 |
| — | REST | GRIA2 | Negative Regulation | We provide multiple lines of evidence that the N-terminal domain of REST represses transcription of the GluR2 and type II sodium-channel genes by recruiting the corepressor Sin3A and histone deacetylase (HDAC) to the promoter region in nonneuronal cells. | 10491605 |
| — | REST | SCN2A | Negative Regulation | We provide multiple lines of evidence that the N-terminal domain of REST represses transcription of the GluR2 and type II sodium-channel genes by recruiting the corepressor Sin3A and histone deacetylase (HDAC) to the promoter region in nonneuronal cells. | 10491605 |
| — | ZEB1 | CD4 | Binding | We show that ZEB binds to the 5'E-box in the CD4-3 element of the proximal CD4 enhancer in competition with the transcriptional activators E12 and HEB, thereby reducing CD4 expression on CD4 single-positive but not CD4/CD8 double-positive T cells. | 10508188 |
| — | ZEB1 | CD4 | Negative Regulation | We show that ZEB binds to the 5'E-box in the CD4-3 element of the proximal CD4 enhancer in competition with the transcriptional activators E12 and HEB, thereby reducing CD4 expression on CD4 single-positive but not CD4/CD8 double-positive T cells. | 10508188 |
| — | TCF3 | CD4 | Binding | We show that ZEB binds to the 5'E-box in the CD4-3 element of the proximal CD4 enhancer in competition with the transcriptional activators E12 and HEB, thereby reducing CD4 expression on CD4 single-positive but not CD4/CD8 double-positive T cells. | 10508188 |
| — | TCF3 | CD4 | Positive Regulation | We show that ZEB binds to the 5'E-box in the CD4-3 element of the proximal CD4 enhancer in competition with the transcriptional activators E12 and HEB, thereby reducing CD4 expression on CD4 single-positive but not CD4/CD8 double-positive T cells. | 10508188 |
| — | Tcf12 | CD4 | Binding | We show that ZEB binds to the 5'E-box in the CD4-3 element of the proximal CD4 enhancer in competition with the transcriptional activators E12 and HEB, thereby reducing CD4 expression on CD4 single-positive but not CD4/CD8 double-positive T cells. | 10508188 |
| — | Tcf12 | CD4 | Positive Regulation | We show that ZEB binds to the 5'E-box in the CD4-3 element of the proximal CD4 enhancer in competition with the transcriptional activators E12 and HEB, thereby reducing CD4 expression on CD4 single-positive but not CD4/CD8 double-positive T cells. | 10508188 |
| — | WT1 | ODC1 | Negative Regulation | Simultaneous mutation of the WT1-binding motif and the two E-boxes completely abolished inhibition by WT1 of ODC promoter activity. | 10047468 |
| — | WT1 | ODC1 | Binding | Simultaneous mutation of the WT1-binding motif and the two E-boxes completely abolished inhibition by WT1 of ODC promoter activity. | 10047468 |
| Increased | AR | KLK3 | Binding | In addition, when nuclear AR from forskolin-treated LNCaP cells was incubated with oligonucleotides encoding an androgen response element of the PSA promoter and examined by electromobility shift assay, an increase in AR-androgen response element complex formation was observed. | 10075669 |
| Increased | STAT6 | IRF1 | Negative Regulation | In a cell line with low endogenous Stat6, increasing levels of activated Stat6 at constant doses of IFN-gamma and IL-4 leads to inhibition of the IRF-1 promoter. | 10528163 |
| — | TP53 | ALB | Negative Regulation | We show that p53 wild type and tumor-derived p53 mutations repress C/EBP-mediated transactivation of the albumin promoter. | 10542249 |
| Mutant | TP53 | ALB | Negative Regulation | We show that p53 wild type and tumor-derived p53 mutations repress C/EBP-mediated transactivation of the albumin promoter. | 10542249 |
| — | Irf1 | Ciita | Positive Regulation | Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-alpha. | 10505975 |
| — | Irf1 | Ciita | Positive Regulation | Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-alpha. | 10505975 |
| — | Irf1 | Ciita | Positive Regulation | Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-alpha. | 10505975 |
| — | Irf1 | Ciita | Positive Regulation | Differential selectivity of CIITA promoter activation by IFN-gamma and IRF-1 in astrocytes and macrophages: CIITA promoter activation is not affected by TNF-alpha. | 10505975 |
| Increased | MYC | CCND2 | Positive Regulation | Addition of trichostatin A to quiescent cells mimics activation of Myc and induces cyclin D2 expression, suggesting that cyclin D2 is repressed in a histone deacetylase-dependent manner in quiescent cells. | 10508165 |
| — | Stat6 | SELP | Positive Regulation | The sustained activation of Stat6 induced by IL-4 is likely to be a key factor leading to the prolonged activation of the P-selectin promoter, thereby resulting in prolonged P-selectin upregulation. | 10364072 |
| — | TCF7L2 | MMP7 | Binding | The matrilysin promoter is upregulated as much as 12-fold by beta-catenin in colon tumor cell lines in a manner inversely proportional to the endogenous levels of beta-catenin/Tcf complex and is dependent upon a single optimal Tcf-4 recognition site. | 10362259 |
| — | TCF7L2 | MMP7 | Positive Regulation | The matrilysin promoter is upregulated as much as 12-fold by beta-catenin in colon tumor cell lines in a manner inversely proportional to the endogenous levels of beta-catenin/Tcf complex and is dependent upon a single optimal Tcf-4 recognition site. | 10362259 |
| — | GATA1 | SPTB | Binding | Using transfection of promoter/reporter plasmids in human tissue culture cell lines, in vitro DNase I footprinting analyses, and gel mobility shift assays, a beta-spectrin gene erythroid promoter with two binding sites for GATA-1 and one site for CACCC-related proteins was identified. | 10037687 |
| Mutant | JUN | CCL5 | Negative Regulation | A c-Jun mutant which lacks a transcriptional activation domain interfered in the activation of the RANTES promoter. | 10075858 |
| — | CEBPB | CEBPA | Binding | This decrease in Sp1 level early in the differentiation program appears to facilitate access of C/EBPbeta and/or C/EBPdelta to the C/EBP regulatory element and, thereby, derepression of the C/EBPalpha gene. | 10373535 |
| — | CEBPD | CEBPA | Binding | This decrease in Sp1 level early in the differentiation program appears to facilitate access of C/EBPbeta and/or C/EBPdelta to the C/EBP regulatory element and, thereby, derepression of the C/EBPalpha gene. | 10373535 |
| — | CEBPB | CEBPA | Positive Regulation | This decrease in Sp1 level early in the differentiation program appears to facilitate access of C/EBPbeta and/or C/EBPdelta to the C/EBP regulatory element and, thereby, derepression of the C/EBPalpha gene. | 10373535 |
| — | CEBPD | CEBPA | Positive Regulation | This decrease in Sp1 level early in the differentiation program appears to facilitate access of C/EBPbeta and/or C/EBPdelta to the C/EBP regulatory element and, thereby, derepression of the C/EBPalpha gene. | 10373535 |
| Reduced | SP1 | CEBPA | Negative Regulation | This decrease in Sp1 level early in the differentiation program appears to facilitate access of C/EBPbeta and/or C/EBPdelta to the C/EBP regulatory element and, thereby, derepression of the C/EBPalpha gene. | 10373535 |
| — | MYC | AR | Binding | Multiple androgen response elements and a Myc consensus site in the androgen receptor (AR) coding region are involved in androgen-mediated up-regulation of AR messenger RNA. | 10551783 |
| — | ETS1 | FLT1 | Positive Regulation | In vitro data also point to a role of Ets-1 as a transcriptional activator of Flt-1. | 10554042 |
| Increased | Esr2 | Prl | Positive Regulation | We conclude that 1) both ER beta and TERP messenger RNAs in GH3 cells are increased by estradiol in a dose- and time-dependent manner, whereas ER alpha is not altered; 2) a 58-kDa ER beta protein is expressed in both the pituitary and GH3 cells; and 3) overexpression of ER beta increases estrogen-induced PRL gene expression. | 10342855 |
| — | Preb | Prl | Positive Regulation | Transient transfection employing PREB-negative C6 rat glial cells showed that PREB is as active as, and additive with, Pit-1 in transactivation of a PRL promoter construct, and that PREB, but not Pit-1, can mediate transcriptional activation by protein kinase A (PKA). | 10194769 |
| — | Pou1f1 | Prl | Positive Regulation | Transient transfection employing PREB-negative C6 rat glial cells showed that PREB is as active as, and additive with, Pit-1 in transactivation of a PRL promoter construct, and that PREB, but not Pit-1, can mediate transcriptional activation by protein kinase A (PKA). | 10194769 |
| — | STAT1 | Socs3 | Binding | A STAT-1/STAT-3 binding element, located at nucleotides -72 to -64, was essential for LIF stimulation of SOCS-3 promoter activity. | 10359822 |
| — | STAT3 | Socs3 | Binding | A STAT-1/STAT-3 binding element, located at nucleotides -72 to -64, was essential for LIF stimulation of SOCS-3 promoter activity. | 10359822 |
| — | Pou2f1 | Ly6e | Binding | The complexity of IFN-mediated regulation of the murine Ly-6E gene in T cell lines is highlighted by the following observations: 1) multiple regulatory regions are present within different parts of the Ly-6E promoter and are necessary for IFN inducibility of the Ly-6E gene, 2) multiple transcription factors including Oct-1 and Oct-2 and the high mobility group (HMG) protein HMGI(Y) bind to regulatory elements present within the G region required for both IFN-alphabeta and IFN-gamma responses, 3) mutational analysis of the G region reveals that a complex interaction exists between the factors binding to this region as shown by their mutual interdependence for detection in DMSA, and 4) inhibition of expression of HMG proteins by antisense HMGI-C RNA in EL4 cells causes the loss of IFN-alphabeta and IFN-gamma inducibility of the endogenous Ly-6 gene. | 10395674 |
| — | Pou2f2 | Ly6e | Binding | The complexity of IFN-mediated regulation of the murine Ly-6E gene in T cell lines is highlighted by the following observations: 1) multiple regulatory regions are present within different parts of the Ly-6E promoter and are necessary for IFN inducibility of the Ly-6E gene, 2) multiple transcription factors including Oct-1 and Oct-2 and the high mobility group (HMG) protein HMGI(Y) bind to regulatory elements present within the G region required for both IFN-alphabeta and IFN-gamma responses, 3) mutational analysis of the G region reveals that a complex interaction exists between the factors binding to this region as shown by their mutual interdependence for detection in DMSA, and 4) inhibition of expression of HMG proteins by antisense HMGI-C RNA in EL4 cells causes the loss of IFN-alphabeta and IFN-gamma inducibility of the endogenous Ly-6 gene. | 10395674 |
| — | Hmga1 | Ly6e | Binding | The complexity of IFN-mediated regulation of the murine Ly-6E gene in T cell lines is highlighted by the following observations: 1) multiple regulatory regions are present within different parts of the Ly-6E promoter and are necessary for IFN inducibility of the Ly-6E gene, 2) multiple transcription factors including Oct-1 and Oct-2 and the high mobility group (HMG) protein HMGI(Y) bind to regulatory elements present within the G region required for both IFN-alphabeta and IFN-gamma responses, 3) mutational analysis of the G region reveals that a complex interaction exists between the factors binding to this region as shown by their mutual interdependence for detection in DMSA, and 4) inhibition of expression of HMG proteins by antisense HMGI-C RNA in EL4 cells causes the loss of IFN-alphabeta and IFN-gamma inducibility of the endogenous Ly-6 gene. | 10395674 |
| — | SP3 | CDKN1A | Positive Regulation | Taken together, these results suggest that histone deacetylase inhibitor up-regulates p21/WAF1/Cip1 transcription by Sp3 but not by Sp1. | 10485470 |
| Increased | Otx2 | NCAM1 | Positive Regulation | In addition, transient expression of Otx2 in COS7 cells is able to dramatically enhance the transcriptional activity of the NCAM promoter. | 10216227 |
| — | CTCF | APP | Positive Regulation | These results suggest that CTCF is pivotal for the up-regulation of APP expression during synaptogenesis in primary neurons. | 10582586 |
| — | JUN | CCND1 | Binding | p300 activated the cyclin D1 promoter through an activator protein-1 (AP-1) site at -954 and was identified within a DNA-bound complex with c-Jun at the AP-1 site. | 10567390 |
| — | PGR | IRS2 | Positive Regulation | Our analysis of the regulation of IRS-2 in HeLa cell models shows that synergistic induction of IRS-2 by cAMP and RU486 can be mediated by progesterone receptors (PR) and glucocorticoid receptors (GR) and occurs through a relative slow mechanism that requires ongoing protein synthesis. | 10077005 |
| — | NR3C1 | IRS2 | Positive Regulation | Our analysis of the regulation of IRS-2 in HeLa cell models shows that synergistic induction of IRS-2 by cAMP and RU486 can be mediated by progesterone receptors (PR) and glucocorticoid receptors (GR) and occurs through a relative slow mechanism that requires ongoing protein synthesis. | 10077005 |
| — | Sp1 | FASLG | Binding | Nuclear extracts of Sertoli cells contain Sp1 and Sp3 that specifically binds to the Sp1 motif present in the FasL gene, and overexpression of Sp1 but not Sp3 leads to a further increase of transcription from the FasL promoter-enhancer region. | 10075666 |
| — | SP3 | FASLG | Binding | Nuclear extracts of Sertoli cells contain Sp1 and Sp3 that specifically binds to the Sp1 motif present in the FasL gene, and overexpression of Sp1 but not Sp3 leads to a further increase of transcription from the FasL promoter-enhancer region. | 10075666 |
| Increased | Sp1 | FASLG | Positive Regulation | Nuclear extracts of Sertoli cells contain Sp1 and Sp3 that specifically binds to the Sp1 motif present in the FasL gene, and overexpression of Sp1 but not Sp3 leads to a further increase of transcription from the FasL promoter-enhancer region. | 10075666 |
| — | ATF2 | TNF | Negative Regulation | Taken together, our findings suggest that ATF2 contributes to UVC-induced apoptosis through transcriptional silencing of TNFalpha, which balances Fas-mediated cell death in melanoma. | 10318823 |
| — | PPARA | NR1D1 | Positive Regulation | Transfection studies with reporter constructs driven by the human Rev-erbalpha promoter revealed that fibrates induce Rev-erbalpha expression at the transcriptional level via PPARalpha. | 10076997 |
| — | SP1 | MYBL2 | Binding | When the SP1 elements of the B-myb promoter are transferred in front of a heterologous promoter, an increased response to B-MYB results. | 10022815 |
| — | MYBL2 | MYBL2 | Positive Regulation | When the SP1 elements of the B-myb promoter are transferred in front of a heterologous promoter, an increased response to B-MYB results. | 10022815 |
| — | SP1 | CDKN1A | Positive Regulation | Taken together, these results suggest that Sp1 or Sp1-related proteins mediate FB1-induced activation of the p21 promoter. | 10212208 |
| — | NR2F1 | EGR1 | Positive Regulation | In fact, the coactivators p300 and steroid receptor activator 1 can enhance the transactivation of the NGFI-A promoter induced by COUP-TFI. | 10082539 |
| — | NRF1 | CXCR4 | Positive Regulation | HTLV type I Tax activation of the CXCR4 promoter by association with nuclear respiratory factor 1. | 10381170 |
| — | MAX | CCND2 | Negative Regulation | The cyclin D2 promoter is repressed by Mad-Max complexes and de-repressed by Myc via a single highly conserved E-box element. | 10508165 |
| — | MYC | CCND2 | Positive Regulation | The cyclin D2 promoter is repressed by Mad-Max complexes and de-repressed by Myc via a single highly conserved E-box element. | 10508165 |
| Reduced | Tfcp2 | Hba-a2 | Positive Regulation | During HMBA-induced terminal differentiation of antisense CP2 expressing MEL cells, the transcription of endogenous alpha-globin gene was suppressed as expected. | 10491335 |
| Reduced | Tfcp2 | Hba-a1 | Positive Regulation | During HMBA-induced terminal differentiation of antisense CP2 expressing MEL cells, the transcription of endogenous alpha-globin gene was suppressed as expected. | 10491335 |
| — | CDX2 | GCG | Neutral Regulation | Further, we found that the presence of cdx-2 enhanced the interaction of pax-6 with p300, thus establishing a molecular complex of transcription factors implicated in tissue-specific glucagon gene expression with the basal transcriptional machinery. | 10506141 |
| — | PAX6 | GCG | Neutral Regulation | Further, we found that the presence of cdx-2 enhanced the interaction of pax-6 with p300, thus establishing a molecular complex of transcription factors implicated in tissue-specific glucagon gene expression with the basal transcriptional machinery. | 10506141 |
| Increased | CREB1 | IL10 | Neutral Regulation | Our data suggest that intracellular cAMP may directly affect expression of the immunoregulatory cytokine IL-10 in monocytic cells via activation of the eukaryotic transcription factors CREB-1 and ATF-1 and their binding to CRE1 and CRE4 in the upstream enhancer of the IL-10 promoter. | 10540320 |
| Increased | ATF1 | IL10 | Neutral Regulation | Our data suggest that intracellular cAMP may directly affect expression of the immunoregulatory cytokine IL-10 in monocytic cells via activation of the eukaryotic transcription factors CREB-1 and ATF-1 and their binding to CRE1 and CRE4 in the upstream enhancer of the IL-10 promoter. | 10540320 |
| Increased | CREB1 | IL10 | Binding | Our data suggest that intracellular cAMP may directly affect expression of the immunoregulatory cytokine IL-10 in monocytic cells via activation of the eukaryotic transcription factors CREB-1 and ATF-1 and their binding to CRE1 and CRE4 in the upstream enhancer of the IL-10 promoter. | 10540320 |
| Increased | ATF1 | IL10 | Binding | Our data suggest that intracellular cAMP may directly affect expression of the immunoregulatory cytokine IL-10 in monocytic cells via activation of the eukaryotic transcription factors CREB-1 and ATF-1 and their binding to CRE1 and CRE4 in the upstream enhancer of the IL-10 promoter. | 10540320 |
| — | MYC | TERT | Positive Regulation | Since telomerase activation frequently correlates with immortalization and telomerase functions to stabilize telomers in cycling cells, we tested whether Myc-induced activation of TERT gene expression represents an important mechanism through which c-Myc acts to immortalize cells. | 10022128 |
| — | Myc | Tert | Positive Regulation | Employing the rat embryo fibroblast cooperation assay, we show that TERT is unable to substitute for c-Myc in the transformation of primary rodent fibroblasts, suggesting that the transforming activities of Myc extend beyond its ability to activate TERT gene expression and hence telomerase activity. | 10022128 |
| — | ESR1 | H19 | Positive Regulation | We demonstrated that ERalpha up-regulated the H19 promoter in MCF-7 and in HBL-100, whereas PR-A did not have any effect per se. | 10442637 |
| — | Cebpb | TFAP2A | Binding | This novel regulatory scheme involves: (1) unique gradients of expression for each transcription factor, i.e., C/EBPbeta and AP-2 most abundant in the lower epidermis, C/EBPalpha in the upper; (2) C/EBP-binding sites in the ap-2alpha gene promoter, through which C/EBPbeta stimulates ap-2alpha; and (3) AP-2 binding sites in the c/ebpalpha promoter, through which AP-2 represses c/ebpalpha. | 10588870 |
| — | Cebpb | TFAP2A | Positive Regulation | This novel regulatory scheme involves: (1) unique gradients of expression for each transcription factor, i.e., C/EBPbeta and AP-2 most abundant in the lower epidermis, C/EBPalpha in the upper; (2) C/EBP-binding sites in the ap-2alpha gene promoter, through which C/EBPbeta stimulates ap-2alpha; and (3) AP-2 binding sites in the c/ebpalpha promoter, through which AP-2 represses c/ebpalpha. | 10588870 |
| — | SRF | FOS | Positive Regulation | The SRF and bHLH proteins appear to bind to the SRE and activate the c-fos promoter in Sertoli cells. | 10319327 |
| Mutant | SP1 | CGB3 | Positive Regulation | However, cAMP stimulation of the CGbeta promoter is reduced by AP-2 mutations, whereas Sp1 mutations enhance cAMP activation. | 10551788 |
| — | NFKB1 | NFKBIA | Binding | Prolonged NF-kappaB binding and a temporal switch in the composition of NF-kappaB complexes bound to the -63 to -53 kappaB1 site of the IkappaBalpha promoter were also observed; with time after induction, decreased levels of transcriptionally active p50-p65 and increased p50-c-Rel heterodimers were detected at the kappaB1 site. | 10454561 |
| Reduced | RELA | NFKBIA | Binding | Prolonged NF-kappaB binding and a temporal switch in the composition of NF-kappaB complexes bound to the -63 to -53 kappaB1 site of the IkappaBalpha promoter were also observed; with time after induction, decreased levels of transcriptionally active p50-p65 and increased p50-c-Rel heterodimers were detected at the kappaB1 site. | 10454561 |
| Increased | REL | NFKBIA | Binding | Prolonged NF-kappaB binding and a temporal switch in the composition of NF-kappaB complexes bound to the -63 to -53 kappaB1 site of the IkappaBalpha promoter were also observed; with time after induction, decreased levels of transcriptionally active p50-p65 and increased p50-c-Rel heterodimers were detected at the kappaB1 site. | 10454561 |
| — | Myc | GCFC2 | Positive Regulation | These results indicate that the G10BP-1 gene is a target of Myc and Jun/Fos and that these factors repress the fibronectin gene expression through induction of G10BP-1 during G1-to-S phase progression. | 10421838 |
| — | JUN | GCFC2 | Positive Regulation | These results indicate that the G10BP-1 gene is a target of Myc and Jun/Fos and that these factors repress the fibronectin gene expression through induction of G10BP-1 during G1-to-S phase progression. | 10421838 |
| — | FOS | GCFC2 | Positive Regulation | These results indicate that the G10BP-1 gene is a target of Myc and Jun/Fos and that these factors repress the fibronectin gene expression through induction of G10BP-1 during G1-to-S phase progression. | 10421838 |
| — | Myc | FN1 | Negative Regulation | These results indicate that the G10BP-1 gene is a target of Myc and Jun/Fos and that these factors repress the fibronectin gene expression through induction of G10BP-1 during G1-to-S phase progression. | 10421838 |
| — | JUN | FN1 | Negative Regulation | These results indicate that the G10BP-1 gene is a target of Myc and Jun/Fos and that these factors repress the fibronectin gene expression through induction of G10BP-1 during G1-to-S phase progression. | 10421838 |
| — | FOS | FN1 | Negative Regulation | These results indicate that the G10BP-1 gene is a target of Myc and Jun/Fos and that these factors repress the fibronectin gene expression through induction of G10BP-1 during G1-to-S phase progression. | 10421838 |
| — | GCFC2 | FN1 | Negative Regulation | These results indicate that the G10BP-1 gene is a target of Myc and Jun/Fos and that these factors repress the fibronectin gene expression through induction of G10BP-1 during G1-to-S phase progression. | 10421838 |
| — | CEBPE | ELANE | Neutral Regulation | These results demonstrate a role for C/EBPepsilon in regulating myeloid promoters, such as neutrophil elastase, probably through a direct interaction with c-myb. | 10233885 |
| — | FLI1 | GP9 | Positive Regulation | In this study, transient cotransfection of several GPIX promoter/reporter constructs into 293T kidney fibroblasts with a Fli-1 expression vector shows that the oncogenic protein Fli-1 can transactivate the GPIX promoter when an intact GPIX Ets site is present. | 10194443 |
| Increased | Pparg | Ucp1 | Positive Regulation | Rodent brown adipocytes express peroxisome proliferator activated receptor-alpha (PPARalpha) and PPARgamma and while the rodent uncoupling protein-1 (UCP-1) gene contains a putative peroxisome proliferator response element (PPRE), only PPARgamma activation by thiazolidinediones increase UCP-1 mRNA levels. | 10529360 |
| Increased | Pparg | Ucp1 | Positive Regulation | Rodent brown adipocytes express peroxisome proliferator activated receptor-alpha (PPARalpha) and PPARgamma and while the rodent uncoupling protein-1 (UCP-1) gene contains a putative peroxisome proliferator response element (PPRE), only PPARgamma activation by thiazolidinediones increase UCP-1 mRNA levels. | 10529360 |
| — | Dbp | Cyp2a4 | Neutral Regulation | Biochemical evidence, including in vitro DNase I footprinting on the Cyp2a4 and Cyp2a5 promoters and cotransfection experiments with the human hepatoma cell line HepG2, suggests that the Cyp2a4 and Cyp2a5 genes are indeed regulated by DBP. | 10490589 |
| — | Dbp | Cyp2a5 | Neutral Regulation | Biochemical evidence, including in vitro DNase I footprinting on the Cyp2a4 and Cyp2a5 promoters and cotransfection experiments with the human hepatoma cell line HepG2, suggests that the Cyp2a4 and Cyp2a5 genes are indeed regulated by DBP. | 10490589 |
| — | Neurod2 | Itpr1 | Neutral Regulation | From these results, we suggest that NDRF is involved in the tissue-specific regulation of IP3R1 gene expression in the CNS. | 10098882 |
| — | STAT4 | IRF1 | Positive Regulation | Strong IL-12-dependent activation of a reporter gene construct containing the IRF-1 IFN-gamma-activated sequence element provides further evidence for the key role of signal transducer and activator of transcription-4 in the IL-12-induced up-regulation of IRF-1 transcripts in T cells. | 10037767 |
| Reduced | Pdx1 | INS | Binding | Importantly, the lower Pdx-1 protein levels led to a greater than 50% reduction in Pdx-1 binding activity to the A3 element on the insulin gene promoter, and a significant reduction in insulin mRNA levels. | 10393088 |
| — | CUX1 | TGFBR2 | Binding | Human cut-like repressor protein binds TGFbeta type II receptor gene promoter. | 10545217 |
| — | MYBL2 | COL5A2 | Negative Regulation | A model of indirect repression of the Col5A2 gene by B-Myb, via interaction with a positively-acting matrix regulatory factor, termed MRF-V, is discussed. | 10429946 |
| — | SP1 | CYP11A1 | Positive Regulation | Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA. | 10446912 |
| — | NR5A1 | STAR | Positive Regulation | Thus, transcriptional activation of the StAR gene by a steroidogenic factor-1-dependent mechanism may represent a common pathway for ACTH (protein kinase A) and AII action in stimulating steroid production in the adrenal fasciculata and glomerulosa. | 10499490 |
| — | PPARG | LPL | Positive Regulation | Cotransfection of COUP-TF expression constructs in the renal epithelial 293T cell line significantly increased transcription from the LPL promoter in synergy with PPARgamma2/RXRalpha heterodimers. | 10098492 |
| — | RXRA | LPL | Positive Regulation | Cotransfection of COUP-TF expression constructs in the renal epithelial 293T cell line significantly increased transcription from the LPL promoter in synergy with PPARgamma2/RXRalpha heterodimers. | 10098492 |
| — | STAT3 | HSP90AB1 | Positive Regulation | Recent studies have shown that the cytokine IL-6 activates hsp 90 gene expression via specific transcription factors that include STAT-3 (signal transducer and activator of transcription 3). | 10447736 |
| — | SP1 | LDLR | Positive Regulation | Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein. | 10224053 |
| — | YY1 | LDLR | Negative Regulation | Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein. | 10224053 |
| — | CREB1 | TH | Neutral Regulation | These results support the hypothesis that CREB (not other CRE-binding proteins) is the key transcription factor that is required for regulating TH gene expression in response to cAMP. | 10407170 |
| — | Stat5a | PRLR | Positive Regulation | Our results suggest that GH and PRL increase the levels of exon 1A- and 1C-containing PRLR mRNA species and furthermore that the transcriptional activity of the 1A promoter is increased via activation of STAT5a and STAT5b. | 10373481 |
| — | STAT5B | PRLR | Positive Regulation | Our results suggest that GH and PRL increase the levels of exon 1A- and 1C-containing PRLR mRNA species and furthermore that the transcriptional activity of the 1A promoter is increased via activation of STAT5a and STAT5b. | 10373481 |
| — | TP53 | BAX | Neutral Regulation | Our results show that the large E1B proteins very efficiently inhibited the activity of p53 on the Bax, p21(Waf1), cyclin G, and MDM2 reporter constructs but had no effect on the activation of the same reporter constructs by p73, with the exception of some inhibition of the Bax promoter by Ad12 E1B. | 10207112 |
| — | TP53 | CDKN1A | Neutral Regulation | Our results show that the large E1B proteins very efficiently inhibited the activity of p53 on the Bax, p21(Waf1), cyclin G, and MDM2 reporter constructs but had no effect on the activation of the same reporter constructs by p73, with the exception of some inhibition of the Bax promoter by Ad12 E1B. | 10207112 |
| — | TP53 | CCNG1 | Neutral Regulation | Our results show that the large E1B proteins very efficiently inhibited the activity of p53 on the Bax, p21(Waf1), cyclin G, and MDM2 reporter constructs but had no effect on the activation of the same reporter constructs by p73, with the exception of some inhibition of the Bax promoter by Ad12 E1B. | 10207112 |
| — | TP53 | MDM2 | Neutral Regulation | Our results show that the large E1B proteins very efficiently inhibited the activity of p53 on the Bax, p21(Waf1), cyclin G, and MDM2 reporter constructs but had no effect on the activation of the same reporter constructs by p73, with the exception of some inhibition of the Bax promoter by Ad12 E1B. | 10207112 |
| — | TP73 | BAX | Positive Regulation | Our results show that the large E1B proteins very efficiently inhibited the activity of p53 on the Bax, p21(Waf1), cyclin G, and MDM2 reporter constructs but had no effect on the activation of the same reporter constructs by p73, with the exception of some inhibition of the Bax promoter by Ad12 E1B. | 10207112 |
| — | TP73 | CDKN1A | Positive Regulation | Our results show that the large E1B proteins very efficiently inhibited the activity of p53 on the Bax, p21(Waf1), cyclin G, and MDM2 reporter constructs but had no effect on the activation of the same reporter constructs by p73, with the exception of some inhibition of the Bax promoter by Ad12 E1B. | 10207112 |
| — | TP73 | CCNG1 | Positive Regulation | Our results show that the large E1B proteins very efficiently inhibited the activity of p53 on the Bax, p21(Waf1), cyclin G, and MDM2 reporter constructs but had no effect on the activation of the same reporter constructs by p73, with the exception of some inhibition of the Bax promoter by Ad12 E1B. | 10207112 |
| — | TP73 | MDM2 | Positive Regulation | Our results show that the large E1B proteins very efficiently inhibited the activity of p53 on the Bax, p21(Waf1), cyclin G, and MDM2 reporter constructs but had no effect on the activation of the same reporter constructs by p73, with the exception of some inhibition of the Bax promoter by Ad12 E1B. | 10207112 |
| — | VDR | RARB | Negative Regulation | Vitamin D represses retinoic acid-dependent transactivation of the retinoic acid receptor-beta2 promoter: the AF-2 domain of the vitamin D receptor is required for transrepression. | 10342883 |
| — | RELA | BCL2L1 | Positive Regulation | Co-transfection experiment using a bcl-x promoter reporter construct and an expression vector for NF-kappaB p50 or p65 indicates that p65, but not p50, up-regulates the promoter activity of the bcl-x gene. | 10585435 |
| — | SPI1 | NCF1 | Binding | We conclude that the immediate flanking nucleotides of the PU.1 consensus motif have significant effects on PU.1 binding avidity and activity and that this region is the dominant cis element regulating p47phox expression. | 10542290 |
| — | SPI1 | NCF1 | Neutral Regulation | We conclude that the immediate flanking nucleotides of the PU.1 consensus motif have significant effects on PU.1 binding avidity and activity and that this region is the dominant cis element regulating p47phox expression. | 10542290 |
| — | Runx2 | Runx2 | Positive Regulation | We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding sites characterized. | 10215629 |
| — | Runx2 | Runx2 | Binding | We also show that Cbfa1 regulates positively the activity of its own promoter, which has the highest affinity Cbfa1-binding sites characterized. | 10215629 |
| — | CEBPB | CEBPB | Positive Regulation | Interestingly, the C/EBPbeta promoter is not activated by C/EBPalpha, another C/EBP family member highly expressed in myelomonocytic cells, indicating that the autoregulation is specific for C/EBPbeta. | 10542314 |
| — | E2f1 | E2f1 | Positive Regulation | These results suggest that PARP plays a role in the induction of E2F-1 promoter activity, which then positively regulates both E2F-1 and pol alpha expression, when quiescent cells reenter the cell cycle upon recovery from aphidicolin exposure or removal of serum. | 10490838 |
| — | E2f1 | POLA1 | Positive Regulation | These results suggest that PARP plays a role in the induction of E2F-1 promoter activity, which then positively regulates both E2F-1 and pol alpha expression, when quiescent cells reenter the cell cycle upon recovery from aphidicolin exposure or removal of serum. | 10490838 |
| — | Sp1 | Cdkn1a | Positive Regulation | Furthermore, p300 was able to act as a co-activator for Sp1-mediated transcriptional activation in PC12 cells, suggesting that p300 and Sp1 may cooperate in activating p21 transcription during the withdrawal of neuronal precursors from the cell cycle. | 10362258 |
| — | IRF1 | CIITA | Binding | Here we report that the human CIITA Type IV promoter IRF-E binds IRF-1 and can be activated by exogenous expression of IRF-1. | 10557076 |
| Increased | IRF1 | CIITA | Positive Regulation | Here we report that the human CIITA Type IV promoter IRF-E binds IRF-1 and can be activated by exogenous expression of IRF-1. | 10557076 |
| Increased | Srebf1 | Scarb1 | Neutral Regulation | The cysteine protease inhibitor N-acetyl-leucyl-leucyl-norleucinal, which inhibits SREBP degradation, enhanced the effect of SREBP-1a on the regulation of the rat HDL receptor SR-BI gene. | 10579331 |
| — | SP1 | PSEN1 | Binding | Thus, transfection and footprinting assays correlate to suggest that Sp1 transcription factor(s) bind at several sites upstream and downstream from the initiation site and activate the transcription of the PS1 promoter. | 10446206 |
| — | SP1 | PSEN1 | Positive Regulation | Thus, transfection and footprinting assays correlate to suggest that Sp1 transcription factor(s) bind at several sites upstream and downstream from the initiation site and activate the transcription of the PS1 promoter. | 10446206 |
| — | NEUROD1 | AK1 | Positive Regulation | The CAT reporter assay of the 5'-flanking region of the AK1 gene suggests that NeuroD activates the AK1 expression through E-boxes in the promoter region. | 10101232 |
| Altered_Function | RUNX1 | BCL2 | Positive Regulation | However, AML1/ETO can also activate the BCL-2 promoter and cause enhanced hematopoietic progenitor self-renewal in vitro, suggesting gain-of-functions unique to the fusion protein. | 10208431 |
| — | ESR1 | HRAS | Binding | Our data demonstrate a direct (i) interaction of c-Ha-ras sequence with estrogen receptor and (ii) stimulatory effect of estrogen on c-Ha-ras gene transcription and suggest that alteration in transcriptional regulation of c-Ha-ras gene by estrogen may play an important role in progression of breast cancer. | 10521493 |
| — | ATF2 | CCND1 | Binding | We show that ATF-2 homodimers and ATF-2/c-Jun heterodimers, but not c-Jun homodimers, were able to bind the CRE of the cyclin D1 promoter. | 10500157 |
| — | JUN | CCND1 | Binding | We show that ATF-2 homodimers and ATF-2/c-Jun heterodimers, but not c-Jun homodimers, were able to bind the CRE of the cyclin D1 promoter. | 10500157 |
| — | MYC | TERT | Positive Regulation | Here, we identify the c-Myc transcription factor as a direct mediator of telomerase activation in primary human fibroblasts through its ability to specifically induce TERT gene expression. | 10022128 |
| Reduced | ESRRA | CYP19A1 | Positive Regulation | Because toxaphene is not an inhibitor of aromatase, it is thought that the decrease of the aromatase activity in ERR alpha-1 transfected HepG2 cells following toxaphene treatment resulted from a suppression of the aromatase expression by toxaphene acting as the antagonist of ERR alpha-1. | 10493499 |
| — | WT1 | MYCN | Negative Regulation | Here, we show that the proto-oncogene N-myc promoter was down-regulated by WT1 in transient transfection assays. | 10470095 |
| — | CEBPA | ALB | Binding | The binding of C/EBPalpha or -beta to its cognate sequence in the albumin promoter is not inhibited by p53 expression. | 10542249 |
| — | CEBPB | ALB | Binding | The binding of C/EBPalpha or -beta to its cognate sequence in the albumin promoter is not inhibited by p53 expression. | 10542249 |
| — | RBPJ | IL6 | Binding | Interaction of the nuclear protein CBF1 with the kappaB site of the IL-6 gene promoter. | 10373597 |
| — | NR5A1 | CYP19A1 | Binding | In endometriosis, however, an aberrantly expressed factor, SF-1, displaces COUP-TF to bind to this same promoter and activates aromatase expression and thus local estrogen biosynthesis. | 10593363 |
| — | NR5A1 | CYP19A1 | Positive Regulation | In endometriosis, however, an aberrantly expressed factor, SF-1, displaces COUP-TF to bind to this same promoter and activates aromatase expression and thus local estrogen biosynthesis. | 10593363 |
| — | NR2F2 | CYP19A1 | Binding | In endometriosis, however, an aberrantly expressed factor, SF-1, displaces COUP-TF to bind to this same promoter and activates aromatase expression and thus local estrogen biosynthesis. | 10593363 |
| — | SP1 | PKM | Neutral Regulation | Functional studies by site-directed mutagenesis on the role of Sp1 in the expression of the pyruvate kinase M and aldolase A genes. | 10023068 |
| — | SP1 | ALDOA | Neutral Regulation | Functional studies by site-directed mutagenesis on the role of Sp1 in the expression of the pyruvate kinase M and aldolase A genes. | 10023068 |
| — | GABPB1 | UTRN | Positive Regulation | Activation of utrophin promoter by heregulin via the ets-related transcription factor complex GA-binding protein alpha/beta. | 10359616 |
| — | GABPA | UTRN | Positive Regulation | Activation of utrophin promoter by heregulin via the ets-related transcription factor complex GA-binding protein alpha/beta. | 10359616 |
| Increased | Myc | CCND2 | Neutral Regulation | We now show that p27 is rapidly and transiently sequestered by cyclin D2-Cdk4 complexes upon activation of Myc and that cyclin D2 is a direct target gene of Myc. | 10508165 |
| Increased | Myc | CCND2 | Binding | We now show that p27 is rapidly and transiently sequestered by cyclin D2-Cdk4 complexes upon activation of Myc and that cyclin D2 is a direct target gene of Myc. | 10508165 |
| — | NR1H4 | FABP6 | Positive Regulation | Deletion and mutation analyses demonstrate that the FXR/RXRalpha heterodimer activates transcription through an inverted repeat bile acid responsive element located in position -160/-148 of the human I-BABP promoter. | 10514450 |
| — | RXRA | FABP6 | Positive Regulation | Deletion and mutation analyses demonstrate that the FXR/RXRalpha heterodimer activates transcription through an inverted repeat bile acid responsive element located in position -160/-148 of the human I-BABP promoter. | 10514450 |
| — | NR1H4 | FABP6 | Binding | Deletion and mutation analyses demonstrate that the FXR/RXRalpha heterodimer activates transcription through an inverted repeat bile acid responsive element located in position -160/-148 of the human I-BABP promoter. | 10514450 |
| — | RXRA | FABP6 | Binding | Deletion and mutation analyses demonstrate that the FXR/RXRalpha heterodimer activates transcription through an inverted repeat bile acid responsive element located in position -160/-148 of the human I-BABP promoter. | 10514450 |
| — | Sp1 | Bax | Neutral Regulation | The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53. | 10510469 |
| — | Sp3 | Bax | Neutral Regulation | The activity of the murine Bax promoter is regulated by Sp1/3 and E-box binding proteins but not by p53. | 10510469 |
| — | NR2C1 | HRH1 | Binding | We have identified a DNA response element (TR2RE-HR) in the 3' flanking region of the human histamine H1 receptor gene as a target for the TR2 orphan receptor, a member of the steroid/thyroid hormone receptor superfamily. | 10391141 |
| — | SP1 | ABCC8 | Positive Regulation | Together, these results indicate that SP1 may mediate transcription initiation of the SUR1 gene. | 10373428 |
| — | CREB1 | TNF | Neutral Regulation | Additional mutagenesis and transfection studies demonstrated that NF-kappaB and CREB/AP-1 are important regulators of inducible TNF promoter activity in primary human T lymphocytes. | 10551799 |
| — | GATA4 | Adora1 | Positive Regulation | These observations suggest that embryonic A1AR expression involves activation of the A1AR promoter by GATA-4 and Nkx2.5. | 10318839 |
| — | NKX2-5 | Adora1 | Positive Regulation | These observations suggest that embryonic A1AR expression involves activation of the A1AR promoter by GATA-4 and Nkx2.5. | 10318839 |
| — | RUNX1 | CR1 | Positive Regulation | Analysis of transcription activities showed that AML1 increased the CR1 promoter activity and that TEL repressed the basal activity of the promoter. | 10597047 |
| — | ETV6 | CR1 | Negative Regulation | Analysis of transcription activities showed that AML1 increased the CR1 promoter activity and that TEL repressed the basal activity of the promoter. | 10597047 |
| — | ETS1 | DDIT3 | Neutral Regulation | Regulation of the human stress response gene GADD153 expression: role of ETS1 and FLI-1 gene products. | 10510472 |
| — | FLI1 | DDIT3 | Neutral Regulation | Regulation of the human stress response gene GADD153 expression: role of ETS1 and FLI-1 gene products. | 10510472 |
| — | MYC | CDH1 | Positive Regulation | Here we show that only a wild type c-myc gene, coding for the two c-Myc proteins c-Myc2 and c-Myc1, was able to transactivate the E-cadherin promoter, in contrast to c-Myc2 or c-Myc1 alone which strongly repressed E-cadherin in both epithelial cells and fibroblasts. | 10523846 |
| — | MYC | CDH1 | Negative Regulation | Here we show that only a wild type c-myc gene, coding for the two c-Myc proteins c-Myc2 and c-Myc1, was able to transactivate the E-cadherin promoter, in contrast to c-Myc2 or c-Myc1 alone which strongly repressed E-cadherin in both epithelial cells and fibroblasts. | 10523846 |
| — | SP3 | SLC2A1 | Binding | In summary, we provide direct evidence that the transcription factor Sp3 represses gene expression in non-muscle and muscle cells and this is likely to operate in fetal heart by binding to the GLUT1 gene promoter. | 10556032 |
| — | SP3 | SLC2A1 | Negative Regulation | In summary, we provide direct evidence that the transcription factor Sp3 represses gene expression in non-muscle and muscle cells and this is likely to operate in fetal heart by binding to the GLUT1 gene promoter. | 10556032 |
| — | GABPB1 | UTRN | Binding | Taken together, these results suggest that the GA-binding protein alpha/beta complex of transcription factors binds and activates the utrophin promoter in response to heregulin-activated extracellular signal-regulated kinase in muscle cell cultures. | 10359616 |
| — | GABPA | UTRN | Binding | Taken together, these results suggest that the GA-binding protein alpha/beta complex of transcription factors binds and activates the utrophin promoter in response to heregulin-activated extracellular signal-regulated kinase in muscle cell cultures. | 10359616 |
| — | GABPB1 | UTRN | Positive Regulation | Taken together, these results suggest that the GA-binding protein alpha/beta complex of transcription factors binds and activates the utrophin promoter in response to heregulin-activated extracellular signal-regulated kinase in muscle cell cultures. | 10359616 |
| — | GABPA | UTRN | Positive Regulation | Taken together, these results suggest that the GA-binding protein alpha/beta complex of transcription factors binds and activates the utrophin promoter in response to heregulin-activated extracellular signal-regulated kinase in muscle cell cultures. | 10359616 |
| — | PDX1 | INS | Binding | Both drugs prevented a rise in blood oxidative stress markers (8-hydroxy-2'-deoxyguanosine and malondialdehyde + 4-hydroxy-2-nonenal), and partially prevented hyperglycemia, glucose intolerance, defective insulin secretion as well as decrements in beta cell insulin content, insulin gene expression, and PDX-1 (STF-1) binding to the insulin gene promoter. | 10485916 |
| Increased | Etv5 | Ifng | Positive Regulation | Retroviral expression of ERM did not restore IFN-gamma production in Stat4-deficient T cells, but augmented IFN-gamma expression in Stat4-heterozygous T cells. | 10097133 |
| Increased | JUN | CGA | Neutral Regulation | This process is accompanied by a decrease in estrogen receptor alpha gene expression as well as an increase in the expression of transcription factors known to regulate the alpha-subunit promoter, such as cJun and P-LIM. | 10478837 |
| Increased | LHX3 | CGA | Neutral Regulation | This process is accompanied by a decrease in estrogen receptor alpha gene expression as well as an increase in the expression of transcription factors known to regulate the alpha-subunit promoter, such as cJun and P-LIM. | 10478837 |
| — | MYB | CCNA1 | Positive Regulation | c-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression. | 10590070 |
| — | FOSL1 | ELN | Negative Regulation | Western blot analysis shows that bFGF induces a sustained increase in the steady-state levels of Fra 1, and co-transfection of a Fra 1 expression vector with an elastin promoter reporter construct results in an inhibition of elastin promoter activity. | 10559225 |
| — | Sp1 | CEBPA | Binding | Sp1 was shown to bind to a GC box at the 5' end of the C/EBP regulatory element in the C/EBPalpha promoter and, in so doing, to competitively prevent binding to and transactivation of the promoter by the C/EBPs. | 10373535 |
| — | Sp1 | CEBPA | Negative Regulation | Sp1 was shown to bind to a GC box at the 5' end of the C/EBP regulatory element in the C/EBPalpha promoter and, in so doing, to competitively prevent binding to and transactivation of the promoter by the C/EBPs. | 10373535 |
| — | CEBPB | Nos2 | Binding | Our results provide evidence that this NF-IL6 binding site is of central importance for maintaining a high transcriptional rate of the iNOS gene after IFN-gamma/LPS stimulation, and that NF-IL6 may cooperate with hypoxia inducible factor-1 in the orchestration of iron-mediated regulation of iNOS. | 10229861 |
| — | CEBPB | Nos2 | Positive Regulation | Our results provide evidence that this NF-IL6 binding site is of central importance for maintaining a high transcriptional rate of the iNOS gene after IFN-gamma/LPS stimulation, and that NF-IL6 may cooperate with hypoxia inducible factor-1 in the orchestration of iron-mediated regulation of iNOS. | 10229861 |
| — | CEBPB | CCL13 | Binding | Among the promoter elements potentially regulating MCP-4 gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-2, a NF-kappaB like consensus sequence, gamma-interferon- response and YY-1 elements as well as glucocorticoid response elements. | 10049733 |
| — | YY1 | CCL13 | Binding | Among the promoter elements potentially regulating MCP-4 gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-2, a NF-kappaB like consensus sequence, gamma-interferon- response and YY-1 elements as well as glucocorticoid response elements. | 10049733 |
| — | CUX1 | TGFBR2 | Binding | In this study, we show that the CDP/Cut (CCAAT displacement protein) transcription factor, a transcriptional repressor, binds both the wild type and the mutant TbetaR-II promoter. | 10545217 |
| — | Myf5 | Myog | Binding | Here we show that transcription of the myogenin gene in differentiated cells correlates with MEF2 and NF1 binding to their cognate sites in the proximal myogenin promoter but not with binding of Myf5 or MyoD to the E-box. | 10548518 |
| — | MYOD1 | Myog | Binding | Here we show that transcription of the myogenin gene in differentiated cells correlates with MEF2 and NF1 binding to their cognate sites in the proximal myogenin promoter but not with binding of Myf5 or MyoD to the E-box. | 10548518 |
| — | Cebpb | Col1a1 | Positive Regulation | Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells. | 10051504 |
| — | Etv4 | Ggt1 | Positive Regulation | Using transient transfection, PEA3 activated transcription of the rat GGT mRNA-IV promoter only in cultured epididymal cells from the rat initial segment, but not in Cos-1 or NRK-52E cells. | 10026114 |
| — | JUN | CDKN1A | Positive Regulation | c-Jun transactivates the promoter of the human p21(WAF1/Cip1) gene by acting as a superactivator of the ubiquitous transcription factor Sp1. | 10506225 |
| — | TFAP2A | EGFR | Binding | HTF can also bind, but with a lower affinity, to a related cis sequence present in the epidermal growth factor receptor promoter. | 10363966 |
| — | CEBPA | Krt10 | Positive Regulation | In cultured cells, C/EBPalpha and C/EBPbeta are each capable of activating the k10 promoter via three binding sites, identified by site-directed mutagenesis. | 10588870 |
| — | CEBPB | Krt10 | Positive Regulation | In cultured cells, C/EBPalpha and C/EBPbeta are each capable of activating the k10 promoter via three binding sites, identified by site-directed mutagenesis. | 10588870 |
| — | CEBPA | Krt10 | Binding | In cultured cells, C/EBPalpha and C/EBPbeta are each capable of activating the k10 promoter via three binding sites, identified by site-directed mutagenesis. | 10588870 |
| — | CEBPB | Krt10 | Binding | In cultured cells, C/EBPalpha and C/EBPbeta are each capable of activating the k10 promoter via three binding sites, identified by site-directed mutagenesis. | 10588870 |
| — | TP53 | S100A2 | Positive Regulation | Furthermore, endogenous S100A2 mRNA expression is induced by etoposide in p53 positive, but not in p53 negative cells. | 10094469 |
| — | TP53 | BAX | Binding | In addition, the interaction of p53 with its response element from the bax promoter, as compared with its interaction with its element from the p21 promoter, involves a conformationally distinct form of the protein. | 10559267 |
| — | TP53 | CDKN1A | Binding | In addition, the interaction of p53 with its response element from the bax promoter, as compared with its interaction with its element from the p21 promoter, involves a conformationally distinct form of the protein. | 10559267 |
| — | LRRFIP1 | EGFR | Binding | GC factor (GCF) was reported as a transcriptional regulator that binds to a specific GC-rich sequence in the epidermal growth factor receptor (EGFR) gene promoter and represses its expression. | 10500253 |
| — | LRRFIP1 | EGFR | Negative Regulation | GC factor (GCF) was reported as a transcriptional regulator that binds to a specific GC-rich sequence in the epidermal growth factor receptor (EGFR) gene promoter and represses its expression. | 10500253 |
| — | GCFC2 | EGFR | Binding | GC factor (GCF) was reported as a transcriptional regulator that binds to a specific GC-rich sequence in the epidermal growth factor receptor (EGFR) gene promoter and represses its expression. | 10500253 |
| — | GCFC2 | EGFR | Negative Regulation | GC factor (GCF) was reported as a transcriptional regulator that binds to a specific GC-rich sequence in the epidermal growth factor receptor (EGFR) gene promoter and represses its expression. | 10500253 |
| Increased | IRF1 | SLPI | Negative Regulation | Secretory leukocyte protease inhibitor (SLPI) - a regulator of inflammation and an inhibitor of the LPS response - was identified as a gene repressed after doxycycline induced IRF-1 expression. | 10498899 |
| Mutant | SREBF1 | APOA2 | Binding | SREBP-1 mutants lacking the activation domain bind to their cognate sites and directly repress the apoA-II promoter whereas mutants defective in DNA binding indirectly repress the apoA-II promoter activity, possibly by a squelching mechanism. | 10364076 |
| Mutant | SREBF1 | APOA2 | Negative Regulation | SREBP-1 mutants lacking the activation domain bind to their cognate sites and directly repress the apoA-II promoter whereas mutants defective in DNA binding indirectly repress the apoA-II promoter activity, possibly by a squelching mechanism. | 10364076 |
| Mutant | SREBF1 | APOA2 | Negative Regulation | SREBP-1 mutants lacking the activation domain bind to their cognate sites and directly repress the apoA-II promoter whereas mutants defective in DNA binding indirectly repress the apoA-II promoter activity, possibly by a squelching mechanism. | 10364076 |
| Increased | CEBPB | CXCL8 | Positive Regulation | Taken together these studies indicate that TNF-alpha-induced redox changes in lung epithelial cells are responsible for the transcriptional activation of IL-8 and that coordinate activation of NF-kappaB and NF-IL-6 mediate the response. | 10462040 |
| — | RELA | FAS | Neutral Regulation | Activation-dependent transcriptional regulation of the human Fas promoter requires NF-kappaB p50-p65 recruitment. | 10022897 |
| — | STAT6 | CCL11 | Binding | Electrophoretic mobility shift assays revealed NF-kappa B binding after TNF-alpha stimulation and STAT6 binding after IL-4 stimulation using a DNA probe derived from the eotaxin promoter. | 10586089 |
| — | SP1 | CLCN2 | Positive Regulation | This work suggests that Sp1 and Sp3 activate ClC-2 gene transcription and that reduction in Sp1 and Sp3 at birth explains perinatal downregulation of ClC-2 in the lung. | 10198359 |
| — | Sp3 | CLCN2 | Positive Regulation | This work suggests that Sp1 and Sp3 activate ClC-2 gene transcription and that reduction in Sp1 and Sp3 at birth explains perinatal downregulation of ClC-2 in the lung. | 10198359 |
| — | NCOR1 | TRH | Positive Regulation | TR and RAR can similarly interact with the corepressor proteins, and the cotransfected nuclear receptor corepressor (N-CoR) has been demonstrated to augment the transcriptional stimulation of the TRH gene by unliganded TR. | 10537125 |
| — | HNF4A | ALDH2 | Positive Regulation | Activity of the human aldehyde dehydrogenase 2 promoter is influenced by the balance between activation by hepatocyte nuclear factor 4 and repression by perosixome proliferator activated receptor delta, chicken ovalbumin upstream promoter-transcription factor, and apolipoprotein regulatory protein-1. | 10352676 |
| — | PPARD | ALDH2 | Negative Regulation | Activity of the human aldehyde dehydrogenase 2 promoter is influenced by the balance between activation by hepatocyte nuclear factor 4 and repression by perosixome proliferator activated receptor delta, chicken ovalbumin upstream promoter-transcription factor, and apolipoprotein regulatory protein-1. | 10352676 |
| — | NR2F2 | ALDH2 | Negative Regulation | Activity of the human aldehyde dehydrogenase 2 promoter is influenced by the balance between activation by hepatocyte nuclear factor 4 and repression by perosixome proliferator activated receptor delta, chicken ovalbumin upstream promoter-transcription factor, and apolipoprotein regulatory protein-1. | 10352676 |
| — | LITAF | TNF | Positive Regulation | Together, these findings suggest that LITAF plays an important role in the activation of the human TNF-alpha gene and proposes a new mechanism to control TNF-alpha gene expression. | 10200294 |
| Increased | Msx1 | Msx1 | Negative Regulation | To investigate the molecular mechanism by which Msx1 represses the activity of its own promoter, we transfected C2C12 myoblasts with Msx1-promoter-luciferase constructs and assessed reporter gene activity, with and without the exogenous expression of Msx1. | 10215616 |
| — | ATF2 | JUN | Binding | Supershift assays revealed that, during the early induction phase of the c-jun gene, the proximal activator protein-1 (jun1) site of the c-jun promoter was mainly occupied by the constitutively expressed activating transcription factor-2, whereas the late induction correlated with the predominant binding of c-Jun and, to a lesser extent, activating transcription factor-2 to the distal activator protein-1 (jun2) site. | 10366004 |
| — | JUN | JUN | Binding | Supershift assays revealed that, during the early induction phase of the c-jun gene, the proximal activator protein-1 (jun1) site of the c-jun promoter was mainly occupied by the constitutively expressed activating transcription factor-2, whereas the late induction correlated with the predominant binding of c-Jun and, to a lesser extent, activating transcription factor-2 to the distal activator protein-1 (jun2) site. | 10366004 |
| — | NEUROD1 | NEUROD1 | Positive Regulation | These results raised the possibility that the NeuroD gene expression is positively regulated through the E box sequence, not only by NeuroD itself but also by another E box binding protein. | 10366743 |
| Mutant | TP53 | CDKN1A | Positive Regulation | Furthermore, we found that deletion of the proline-rich region has no or very mild effects on activation of several transiently transfected p53 target gene promoters, i.e., the p21, MDM2, BAX, and GADD45 promoters. | 10321740 |
| Mutant | TP53 | MDM2 | Positive Regulation | Furthermore, we found that deletion of the proline-rich region has no or very mild effects on activation of several transiently transfected p53 target gene promoters, i.e., the p21, MDM2, BAX, and GADD45 promoters. | 10321740 |
| Mutant | TP53 | BAX | Positive Regulation | Furthermore, we found that deletion of the proline-rich region has no or very mild effects on activation of several transiently transfected p53 target gene promoters, i.e., the p21, MDM2, BAX, and GADD45 promoters. | 10321740 |
| Mutant | TP53 | GADD45A | Positive Regulation | Furthermore, we found that deletion of the proline-rich region has no or very mild effects on activation of several transiently transfected p53 target gene promoters, i.e., the p21, MDM2, BAX, and GADD45 promoters. | 10321740 |
| Reduced | NFATC2 | IL4 | Binding | Evidence for suppressed activity of the transcription factor NFAT1 at its proximal binding element P0 in the IL-4 promoter associated with enhanced IL-4 gene transcription in T cells of atopic patients. | 10069428 |
| — | TP53 | BAX | Neutral Regulation | Specifically, we show that expression of alpha6beta4 in carcinoma cells that lack this integrin stimulates an increase in the transactivating function of p53 as demonstrated by the ability of this integrin to up-regulate the expression of a p53-sensitive reporter gene as well as the endogenous p53 response gene, bax. | 10400708 |
| Increased | KLF11 | HBG2 | Positive Regulation | Transfection of K562 cells with FKLF cDNA enhanced the expression of the endogenous epsilon- and gamma-globin genes, suggesting an in vivo role of FKLF in fetal and embryonic globin gene expression. | 10207080 |
| Increased | KLF11 | HBE1 | Positive Regulation | Transfection of K562 cells with FKLF cDNA enhanced the expression of the endogenous epsilon- and gamma-globin genes, suggesting an in vivo role of FKLF in fetal and embryonic globin gene expression. | 10207080 |
| Increased | KLF11 | HBG1 | Positive Regulation | Transfection of K562 cells with FKLF cDNA enhanced the expression of the endogenous epsilon- and gamma-globin genes, suggesting an in vivo role of FKLF in fetal and embryonic globin gene expression. | 10207080 |
| Increased | Nr2f2 | Pklr | Negative Regulation | Overexpression of COUP-TFII abrogated the USF-dependent transactivation of an artificial GlRE-dependent promoter in COS cells and the glucose responsiveness of the L-PK promoter in hepatocytes in primary culture. | 10497199 |
| Reduced | FOS | CLU | Negative Regulation | Here, we demonstrate, by supershift analysis, that JunB, JunD, Fra1, Fra2, and c-Fos bound to AP-1 but that prior treatment of the cells with TGFbeta reduced dramatically c-Fos binding, suggesting that c-Fos might be playing a negative regulatory role in clusterin gene expression. | 10406964 |
| — | SREBF1 | APOA2 | Positive Regulation | Despite the strong transactivation of the apoA-II promoter by SREBP-1 we could not demonstrate significant changes on the endogenous apoA-II mRNA levels of HepG2 cells after cotransfection with SREBP-1 or in the presence or absence of cholesterol and 25-OH-cholesterol. | 10364076 |
| — | SPI1 | CSF2RB | Positive Regulation | We further show that PU.1 has to cooperate with C/EBP proteins to induce beta c transcription. | 10453008 |
| — | Etv4 | Ggt1 | Neutral Regulation | This suggests that PEA3 may be involved in regulating transcription from the rat GGT mRNA-IV gene promoter in the initial segment. | 10026114 |
| — | TP53 | CCNB1 | Neutral Regulation | p53 regulates a G2 checkpoint through cyclin B1. | 10051609 |
| — | SRF | EGR1 | Binding | We conclude that GH stimulates transcription of egr-1 primarily through activation of these Ets factors at multiple sites on the promoter and that stabilization of ternary complexes with SRF at these sites maximizes this response. | 10194767 |
| — | SRF | EGR1 | Positive Regulation | We conclude that GH stimulates transcription of egr-1 primarily through activation of these Ets factors at multiple sites on the promoter and that stabilization of ternary complexes with SRF at these sites maximizes this response. | 10194767 |
| Increased | NFKB2 | TNF | Negative Regulation | Also, overexpression of p52 will suppress activity of TNF promoter reporter gene constructs. | 10595582 |
| — | TEAD1 | TGFA | Binding | We also show that the spacing between the AP-2 and the TEF1 sites in the TGF-alpha promoter has little effect on the transcription from the TGF-alpha promoter. | 10076050 |
| — | Phox2a | DBH | Positive Regulation | Together with our previous studies suggesting a critical role of Phox2a for noradrenergic-specific expression of the DBH gene, these data support a model in which distinct, or partially distinct, molecular mechanisms regulate cell-specific expression of the NET and DBH genes. | 10037744 |
| — | DLX4 | MYC | Neutral Regulation | These results suggest that DLX-7 may regulate c-myc and GATA-1 genes at transcriptional and post-transcriptional levels. | 10402242 |
| — | DLX4 | GATA1 | Neutral Regulation | These results suggest that DLX-7 may regulate c-myc and GATA-1 genes at transcriptional and post-transcriptional levels. | 10402242 |
| — | HSF1 | IL1B | Binding | At least in the case of the IL1B promoter, repression did not seem to involve another factor whose activity is affected by the NSAIDs, NFkappaB as the IL1B promoter fragment used in our studies is not NFkappaB responsive and binds specifically to HSF1. | 10328874 |
| — | TP53 | CDK1 | Negative Regulation | p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor. | 10514438 |
| — | HNF4A | ANG | Binding | In vitro assays indicated that HNF4 bound to the promoter elements and strongly activated the ANG transcription, but that chicken ovalbumin upstream promoter transcription factor (COUP-TF), a transcriptional repressor, dramatically repressed human ANG transcription through the promoter elements and the downstream enhancer core elements. | 10574924 |
| — | HNF4A | ANG | Positive Regulation | In vitro assays indicated that HNF4 bound to the promoter elements and strongly activated the ANG transcription, but that chicken ovalbumin upstream promoter transcription factor (COUP-TF), a transcriptional repressor, dramatically repressed human ANG transcription through the promoter elements and the downstream enhancer core elements. | 10574924 |
| — | NR2F1 | ANG | Negative Regulation | In vitro assays indicated that HNF4 bound to the promoter elements and strongly activated the ANG transcription, but that chicken ovalbumin upstream promoter transcription factor (COUP-TF), a transcriptional repressor, dramatically repressed human ANG transcription through the promoter elements and the downstream enhancer core elements. | 10574924 |
| — | Stat6 | IGHE | Binding | Stat1, which is activated by IFN-gamma, cannot recognize the Stat6-specific IL-4 response element in the epsilon promoter. | 10201928 |
| — | CREB1 | CREBBP | Binding | The inhibitory effect of NFI on transcription of the PEPCK gene induced by the catalytic subunit of protein kinase A appears to be the result of an interaction between NFI and the CREB-binding protein in which NFI competes with CREB for binding to the CREB-binding site on CBP. | 10085123 |
| — | GATA1 | EPB42 | Positive Regulation | Taken together, these results suggest that the erythroid transcription factor GATA-1 plays an important role in the induction of P4.2 gene expression during erythroid cell differentiation. | 10395794 |
| — | NR3C1 | SERPINE1 | Negative Regulation | Here we report that glucocorticoid receptor (GR) represses TGF-beta transcriptional activation of the type-1 plasminogen activator inhibitor (PAI-1) gene in a ligand-dependent manner. | 10518526 |
| — | POU1F1 | PRL | Positive Regulation | Furthermore, CBP also increases the activation of the PRL promoter by GHF-1 and the ligand-independent activation by both wild-type and mutant VDR. | 10406465 |
| — | VDR | PRL | Positive Regulation | Furthermore, CBP also increases the activation of the PRL promoter by GHF-1 and the ligand-independent activation by both wild-type and mutant VDR. | 10406465 |
| Mutant | VDR | PRL | Positive Regulation | Furthermore, CBP also increases the activation of the PRL promoter by GHF-1 and the ligand-independent activation by both wild-type and mutant VDR. | 10406465 |
| — | EBF1 | Blk | Neutral Regulation | These data indicate that EBF plays an important role in the regulation of the Blk promoter in early B cell development and that EBF and BSAP are capable to act in cooperation to induce a target gene. | 10553071 |